Protein kinase Cα-mediated cytotoxic activity of ineupatorolide B from Inula cappa DC. in HeLa cells
نویسندگان
چکیده
منابع مشابه
Protein kinase Cα-mediated cytotoxic activity of ineupatorolide B from Inula cappa DC. in HeLa cells.
There is an ongoing search for plant-derived sesquiterpenes, particularly for those with anticancer activity against human cancer cells. The sesquiterpene ineupatorolide B (InB), isolated from the Inula cappa, showed potent growth-inhibitory activity against HeLa cells but less activity against MM1-CB melanoma cells. Staining by terminal deoxynucleotidyl transferase dUTP nick-end labeling metho...
متن کاملHepatoprotective Activity of Inula Cappa Dc. Aqueous Extract against Carbon Tetrachloride Induced Hepatotoxicity in Wistar Rats
Inula cappa is well known for its medicinal properties like anti-inflammatory, digestive, depurative, carminative, analgesics, antipyretics, treatment of peptic ulcer etc. The present study focuses on the ability of I. cappa to alleviate liver damage caused by over carbon tetrachloride. The aqueous extract of whole plant of I. cappa (400 mg/kg, p.o) significantly showed hepatoprotective activit...
متن کاملProtein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity*
Bones' strength is achieved and maintained through adaptation to load bearing. The role of the protein kinase PKCα in this process has not been previously reported. However, we observed a phenotype in the long bones of Prkca(-/-) female but not male mice, in which bone tissue progressively invades the medullary cavity in the mid-diaphysis. This bone deposition progresses with age and is prevent...
متن کاملProtein kinase Cα mediates erlotinib resistance in lung cancer cells.
Overexpression and mutational activation of the epidermal growth factor receptor (EGFR) plays an important role in the pathogenesis of non-small cell lung cancer (NSCLC). EGFR tyrosine-kinase inhibitors (TKIs) are given as a primary therapy for advanced patients with EGFR-activating mutations; however, the majority of these tumors relapse and patients eventually develop resistance to TKIs. To a...
متن کاملCytotoxic Effect of Hydroalcoholic Extract from Satureja bachtiarica Bunge on Hela Cancer Cells Line
Background & Aim:Cervical cancer is the most common female genital cancer and the second most common cancer in women in the world. Since the herbal ingredients have been used for centuries to treat cancer, purpose of the present study was to determine the cytotoxic effect of hydroalcoholic extract from Satureja bachtiarica Bungeon Hela cancer cells line. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2015
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2015.3172